39 Analysis of Anaphylactic Reactions to Biological Agents Reported to the Italian Pharmacovigilance Database

them, 16 patients (31%) had hypersensitivity reactions with positive cutaneous test, 14 patients (27%) abandoned the investigation and 8 patients (16%) completed the investigation with all tests negative. Currently 12 patients (23%) are being investigated and one of them (2%) performed tests to drugs to use in the next sirgury. The main cause of APEO was latex allergy (22%), followed by NMB hypersensitivity (6%). Three patients had positive tests for 2 different agents. Conclusions: Latex allergy is the main cause of APEO in this study. The importance of testing all the possible agents involved was demonstrated by the occurrence of 3 cases with positive test for 2 agents.